Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (743)
Antibodies (5)

By Effects:	Controls (4) Inhibitors (478) Agonists (10) Antagonists (30) Activators (146) Modulators (25) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P3581

PE 22-28	Inhibitor	99.98%
PE 22-28 is a TREK-1 inhibitor with IC₅₀ value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression.

HY-P1409A

ADWX 1 TFA	Inhibitor	98.37%
ADWX 1 TFA is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 TFA ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 TFA can be used to study T cell-mediated autoimmune diseases.

HY-P2785

Phrixotoxin-1	Inhibitor
Phrixotoxin 1, from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel.

HY-P5931

Spinoxin	Inhibitor	≥98.0%
Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. Spinoxin is a potent inhibitor of Kv1.3 potassium channel (IC₅₀ = 63 nM), considering to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers.

HY-B0341S

Nicorandil-d₄	Activator	99.54%
Nicorandil-d₄ (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].

HY-134320

8-Azido-ATP	Inhibitor
8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase. 8-Azido-ATP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-122024

AZSMO-23	Activator	99.87%
AZSMO-23 is a potent hERG K⁺ channel activator. AZSMO-23 activats WT hERG pre-pulse and tail current with EC₅₀ values of 28.6, 11.2 µM, respectively. AZSMO-23 has the potential for the research of long QT syndrome.

HY-N8404

Chlorahololide C	Inhibitor	≥98.0%
Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC₅₀ of 3.6 μM.

HY-107301

Dehydrosoyasaponin I	Activator	99.56%
Dehydrosoyasaponin I (Soyasaponin Be;DHS-I), a triterpene glycoside, is a potent and reversible calcium-activated potassium (maxi-K) channels activator.

HY-131948

3-Chlorodiphenylamine	Activator	98.74%
3-Chlorodiphenylamine is a high affinity Ca²⁺ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (K_d=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca²⁺-sensitizing compounds due to its small size, and can be used for systolic heart failure research.

HY-B0551

Doxapram	Inhibitor	99.52%
Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

HY-14182

Vernakalant	Inhibitor
Vernakalant(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.

HY-18600

Azimilide	Inhibitor	99.01%
Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.

HY-159506

Bimokalner	Agonist
Bimokalner (Bimokalnerum) is a voltage-gated potassium channel (Kv7.4) agonist.

HY-17412A

Minocycline	Activator
Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.

HY-P0191

Charybdotoxin	Inhibitor
Charybdotoxin, a 37-amino acid peptide, is a K⁺ channel blocker.

HY-18277

MK-7145	Inhibitor
MK-7145 is a ROMK inhibitor, with an IC₅₀ of 0.045 μM.

HY-128829

Kv3 modulator 2	Modulator	99.92%
Kv3 modulator 2 (formula (I)) is a potent Kv3 channels modulator extracted from patent WO2018109484A1, compound formula (I) , has analgesic activity and is used in the prophylaxis or treatment of related disorders.

HY-128831

Kv3 modulator 4	Modulator
Kv3 modulator 4 is a Kv3.1 (pEC₅₀=5.45) and Kv3.2 modulator extracted from patent WO2018020263A1, Cyclobutyl structure.

HY-144801

DDO-02005 free base	Inhibitor
DDO-02005 (free base) is a potent Kv1.5 potassium channel inhibitor with an IC₅₀ value of 0.72 μM. DDO-02005 (free base) has good anti-atrial fibrillation (AF) effect in CaCl₂-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine.

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (743)

Antibodies (5)

Potassium Channel Related Products (743):